(3R,6E)-3-[[(1,1-dimethyllethyl) dimethylsilyl]oxy]-7-[4-(4-fluorophenyl)-6-(1-methyllethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-5-oxo-6-heptenoic acid methyl ester is a compound commonly abbreviated as MPTF.
Properties of the compound:
-Appearance: colorless or light yellow liquid
-Molecular formula: C23H28FN3O6S
-Molecular weight: 491.55g/mol
-Melting point: No data
-Boiling Point: No data
-Solubility: Soluble in organic solvents such as ethers, ketones and alcohols
Use:
MPTF is often used as a probe for nucleophilic tertiary amines applied to dopamine D2 receptors in chemical research. In addition, it can be used to synthesize organic compounds such as pharmaceuticals and pesticides.
Method:
There are many preparation methods and steps for MPTF, depending on the specific synthesis route and reaction conditions. A common preparation method is to react 4-fluorophenylthiazolecarboxamide with 2-methyl-2-thiopyrimidine in the presence of isopropyl carbamate in an appropriate solvent, and further reacted with TButyl compound to obtain the target product.
Safety Information:
MPTF in the laboratory operation and storage process need to pay attention to the following safety information:
-Irritating to skin, contact with skin should be avoided.
-Avoid inhaling aerosols, fumes, dust and vapors of chemical compounds.
-Wear appropriate protective equipment such as gloves, glasses, and face shields when used.
-Store the compound properly after use in a dry, well-ventilated place.
-Use should comply with relevant regulations and safety procedures.